Publications

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Publications

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Citations for each publication can be seen here. All our publications can be found on pubmed. See a short list of selected publications here.

  1. Reis FMCV, Maesta-Pereira S, Ollivier M, Schuette PJ, Sethi E, Miranda BA, Iniguez E, Chakerian M, Vaugh E, Sehgal M, Nguyen DCT, Yuan FTH, Torossian A, Ikebara JM, Kihara AH, Silva AJ, Kao JC, Khakh BS, Adhikari A. Control of feeding by a bottom-up midbrain-subthalamic pathway. Nature Communications. 2024  15, 2111 [pdf]
  2. Gill JL, Schneiders JA, Stangl M, Aghajan ZM, Vallejo M, Hiller S, Topalovic U, Inman CS, Villaroman D, Bari A, Adhikari A, Rao VR, Fanselow MS, Craske MG, Krahl SE, Chen JWY, Vick M, Hasulak NR, Kao JC, Koek RJ, Suthana N, Langevin JP. A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder. Nature Commununications. 2023 May 24;14(1):2997. [pdf]
  3. Fetcho RN, Hall BS, Estrin DJ, Walsh AP, Schuette PJ, Kaminsky J, Singh A, Roshgodal J, Bavley CC, Nadkarni V, Antigua S, Huynh TN, Grosenick L, Carthy C, Komer L, Adhikari A, Lee FS, Rajadhyaksha AM, Liston C. Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships. Nature Commununications. 2023 Apr 29;14(1):2487. [pdf]
  4. Tobias BC, Schuette PJ, Maesta-Pereira S, Torossian A, Wang W, Sethi E, Adhikari A. Characterization of ventromedial hypothalamus activity during exposure to innate and conditioned threats. European Journal of Neuroscience. 2023 Apr;57(7):1053-1067. [pdf]
  5. Reis FMCV, Mobbs D, Canteras NS, Adhikari A. Orchestration of innate and conditioned defensive actions by the periaqueductal gray. Neuropharmacology. 2023 May 1;228:109458. [pdf]
  6. Schuette PJ, Ikebara JM, Maesta-Pereira S, Torossian A, Sethi E, Kihara AH, Kao JC, Reis FMCV, Adhikari A. GABAergic CA1 neurons are more stable following context changes than glutamatergic cells. Scientific Reports. 2022 Jun 20;12(1):10310. [pdf]
  7. La-Vu MQ, Sethi E, Maesta-Pereira S, Schuette PJ, Tobias BC, Reis FMCV, Wang W, Torossian A, Bishop A, Leonard SJ, Lin L, Cahill CM, Adhikari A. Sparse genetically defined neurons refine the canonical role of periaqueductal gray columnar organization. eLife. 2022 Jun 8;11:e77115. doi: 10.7554/eLife.77115. [pdf]
  8. Wang W, Schuette PJ, La-Vu MQ, Torossian A, Tobias BC, Ceko M, Kragel PA, Reis FM, Ji S, Sehgal M, Maesta-Pereira S, Chakerian M, Silva AJ, Canteras NS, Wager T, Kao JC, Adhikari A. Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats. eLife. 2021 Sep 1;10:e69178. [pdf]
  9. Reis FMCV, Liu J, Schuette PJ, Lee JY, Maesta-Pereira S, Chakerian M, Wang W, Canteras NS, Kao JC, Adhikari A. Shared dorsal periaqueductal gray activation patterns during exposure to innate and conditioned threats. Journal of Neurosci. 2021 Apr 21:JN-RM-2450-20. doi: 10.1523/JNEUROSCI.2450-20.2021. [pdf]
  10. Reis FM, Lee JY, Maesta-Pereira S, Schuette PJ, Chakerian M, Liu J, La-Vu MQ, Tobias BC, Ikebara JM, Kihara AH, Canteras NS, Kao JC, Adhikari A. Dorsal periaqueductal gray ensembles represent approach and avoidance states. eLife. 2021 May 6;10:e64934. [pdf]
  11. Wang W, Schuette PJ, Nagai J, Tobias BC, Cuccovia V Reis FM, Ji S, de Lima MAX, La-Vu MQ, Maesta-Pereira S, Chakerian M, Leonard SJ, Lin L, Severino AL, Cahill CM, Canteras NS, Khakh BS, Kao JC, Adhikari A. Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats. Neuron. 2021 Apr 13:S0896-6273(21)00203-8. [pdf]
  12. Zhang Z, Reis FMCV, He Y, Park JW, DiVittorio JR, Sivakumar N, van Veen JE, Maesta-Pereira S, Shum M, Nichols I, Massa MG, Anderson S, Paul K, Liesa M, Ajijola OA, Xu Y,Adhikari A, Correa SM. Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice. Nature Communications. 2020 11(1):6378 [pdf]
  13. Schuette PJ, Reis FMCV, Maesta-Pereira S, Chakerian M, Torossian A, Blair GJ, Wang W, Blair HT, Fanselow MS, Kao JC, Adhikari A. Long-Term Characterization of Hippocampal Remapping during Contextual Fear Acquisition and Extinction.
    Journal of Neuroscience. 2020;40(43):8329-8342 [pdf]
  14. La-Vu M, Tobias BC, Schuette PJ, Adhikari A.To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays.
    Frontiers in Behavioral Neuroscience. 2020 Aug 26;14:145 [pdf]
  15. Kim CK*, Adhikari A*, Deisseroth K. Integration of optogenetics with complementary methodologies in systems neuroscience. Nature Reviews Neuroscience. 2017;18(4):222-235 [pdf]   *equal contributions
  16. Ye L, Allen WE, Thompson KR, Tian Q, Hsueh B, Ramakrishnan C, Wang AC, Jennings JH, Adhikari A, Halpern CH, Witten IB, Barth AL, Luo L, McNab JA, Deisseroth K. Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences. Cell. 2016;165(7):1776-88 [pdf]
  17. Adhikari A*, Lerner TN*, Finkelstein J*, Ferenczi E, Gunaydin LA, Mirzabekov JJ, Ye L, Kim SY, Pak S, Lei A, Deisseroth K. Basomedial amygdala: deep brain target of prefrontal cortex for top-down control of anxiety and fear. Nature. 2015; 527(7577):179-85 2015 [pdf]*equal contributions
  18. Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Tye KM, Anikeeva P, Malenka RC, Deisseroth K. Natural neural projection dynamics underlying social behavior modulation. Cell. 2014; 157(7):1535-51 [pdf]
  19. Adhikari A. Distributed circuits underlying anxiety. Frontiers in Behavioral Neuroscience. 2014; 1;8:112  [pdf]
  20. Kim SY*, Adhikari A*, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature.2013;496:219-223 [pdf] *equal contributions
  21. Tye TM, Mirzabekov J, Warden MR, Tsai H, Finkelstein J, Kim SY, Ferenczi E, Adhikari A, Thompson K, Andalman A, Gunaydin LA, Witten IB, Deisseroth K. Dopamine neurons modulate neural encoding and expression of depression-related behavior. Nature.2013;493(7433):537-41 [pdf]
  22. Warden MR, Selimbeyoglu A, Tye KM, Mirzabekov JJ, Lo M, Kim SY, Adhikari A, Frank LM­ and Deisseroth K. Role of a prefrontal cortex to brainstem projection in responding to behavioral challenge. Nature. 2012; 492(7429):428-32 [pdf]
  23. Adhikari A , Topiwala MA, Gordon JA. Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity. Neuron. 2011; 71(5):898-910 [pdf]
  24. Nason Jr MW,  Adhikari A,  Bozinoski M, Gordon JA, Role LW. Disrupted activity in the hippocampal-accumbens circuit in Type-III neuregulin 1 mutant mice. Neuropsychopharm.2011;36(2):488-96. [pdf]
  25. Adhikari A, Sigurdsson T, Topiwala MA, Gordon JA. Cross-correlation of instantaneous amplitudes of field potential oscillations: a straightforward method to estimate the directionality and lag between brain areas. Journal of Neuroscience Methods. 2010; 191(2):191-200 [pdf]
  26. Adhikari A, Topiwala MA and Gordon JA. Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety. Neuron. 2010; 65(2):257-269 [pdf]
  27. Resende RR, da Costa JL, Kihara AH, Adhikari A, Lorençon E, Britto LR. Intracellular Ca2+ Regulation During Neuronal Differentiation of Murine Embryonal Carcinoma and Mesenchymal Stem Cells. Stem Cells and Development. 2010; 19(3): 379-394 [pdf]
  28. Resende RR, Adhikari A, da Costa JL, Lorençon E, Ladeira MS, Guatimosim S, Kihara AH, Ladeira LO. Influence of spontaneous calcium events on cell-cycle progression in embryonal carcinoma and adult stem cells. Biochimica et Biophysica Acta. 2010; 1803(2):246-2460 [pdf]
  29. Resende RR, Adhikari A. Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation. Cell Communication and Signaling. 2009; 7:7-20 [pdf]
  30. Resende RR, Gomes KN, Adhikari A, Britto LR, Ulrich H. Mechanism of acetylcholine-induced calcium signaling during neuronal differentiation of P19 embryonal carcinoma cells in vitro, Cell Calcium. 2008; 43(2):107-21 [pdf]
  31. Bechara EJ, Dutra F, Cardoso VE, Sartori A, Olympio KP, Penatti CA, Adhikari A, Assunção NA. The dual face of endogenous alpha-aminoketones: pro-oxidizing metabolic weapons. Comparative Biochemistry and Physiology C: Toxicology & Pharmacology 2007; 146(1-2):88-110 [pdf]
  32. Adhikari A, Penatti CA, Resende RR, Ulrich H, Britto LR, Bechara EJ. 5-Aminolevulinate and 4,5-dioxovalerate ions decrease GABAA receptor density in neuronal cells, synaptosomes and rat brain. Brain Research. 2006; 1093(1):95-104 [pdf]

Book Chapters

Gordon JA and Adhikari A, “Learned fear and innate anxiety in rodents and their relevance to human anxiety disorders, ” in Simpson HB, Neria Y, Lewis-Fernandez R, and Schneier F, eds., Anxiety Disorders: Theory, Research and Clinical Perspectives,” Cambridge University Press, Cambridge, England, 2010. [pdf]

Ph.D. Thesis

Adhikari A. Activity in the ventral hippocampal-medial prefrontal cortical pathway during anxiety in mice. Columbia University, 2011. [pdf]